Cancer Research: My goal is to produce
predictive models of the salvage
and de novo dNTP synthesis pathways for eventual applications in
rational optimizations of DNA targeted nucleoside analog cancer therapies. My current focus
is on ribonucleotide reductase (RNR). I am particularly interested in models where quasi-equilibriums of
enzyme complexes are represented
by total concentration constraint systems of polynomials in the free reactant concentrations, see
dTTP-induced R1 dimerization (2008) and my latest
slides.
R Packages:
SBMLR, microarray
data packages and combinatorially complex equilibrium model selection ccems.
Teaching:
Integrative Cancer Biology
2005.
May 2008 updates of some of these R scripts are
available.
Other Links:
cv, my departmental
webpage, the case cran
mirror.
Family:
Left to right are Schuyler, Tom, Carlton, Kirsten, Evan and Cody.
Website maintained by Tom Radivoyevitch .
